Diosmin
- CAS Number
- 520-27-4
- Chemical Name
- Diosmin
HTBA Diosmin is another flavonoid used as a venotonic for the chronic treatment of CVD, varicose veins, hemorrhoids, spider veins, and heavy leg syndrome. Like HTBA Diosmetin, it is a GMP-certified API with an EcoVadis certification, contributing to blood circulation and vascular health.
Properties
- Physical Form
- Powder
Product families
Applications
- Other Pharmaceutical Manufacturing Applications
Product Families
- Active Pharmaceutical Ingredients (APIs)
Other characteristics
- Brand
- HTBA
- Synonyms
3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside, Diosmetin 7-Neohesperidoside, Diosmetin 7-O-Rutinoside, Diosmine, Neodiosmin
- Labeling Claims
Additive-free, Allergen-free, Gluten-free, Halal, Kosher, Non-GMO, Solvent-free, TSE-free; Additive-free; Allergen-free; Gluten-free; Halal; Kosher; Non-GMO; Solvent-free; TSE-free
- Certifications & Compliance
Certificates of Suitability (CEP), ECOVADIS, European Pharmacopeia (Ph. Eur.), FAMI-QS, FSSC 22000, GMP, Halal, Hazard Analysis Critical Control Point (HACCP), ISO 14001, ISO 9001, Kosher, REACH (Europe), United States Pharmacopeia (USP)
- Note
Dissolves in dilute solutions of alkali hydroxides.; The product complies the specification appearing in current Eur. Ph. Monograph.
- Grade
- Pharma Grade
- Markets
- Healthcare & Pharma
- Comments
The product complies the specification appearing in current Eur. Ph. Monograph.
- Appearance
Greyish-yellow or light yellow, hygroscopic powder
- Soluble In
- Dimethyl sulphoxide
- Insoluble In
- Ethanol (96 percent)
- Technology
- Pharmaceuticals & Nutraceuticals
- Identification
A. Infrared absorption spectrophotometry. Comparison: diosmin CRS. B. Examine the chromatograms obtained in the assay. Results: the principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution (a).
- Partially Soluble in
- Water
- Certifications and Compliance
- Certificates of Suitability (CEP)
- ECOVADIS
- European Pharmacopeia (Ph. Eur.)
- FAMI-QS
- FSSC 22000
- GMP
- Halal
- Hazard Analysis Critical Control Point (HACCP)
Technical data
Table 1 of 3
12 rows| Characteristic | Value | Unit | Method |
|---|---|---|---|
| Iodine | max. 0.1 | % | — |
| Acetoisovanillone | max. 0.5 | % | — |
| Hesperidin (B) | max. 4 | % | — |
| 6-iododiosmin (D) | max. 0.6 | % | — |
| Linarin (E) | max. 3 | % | — |
| Diosmetin (F) | max. 2 | % | — |
| Unspecified Impurities | max. 0.4(each impurity) | % | — |
| Total | max. 8.5 | % | — |
| Water | max. 6.0 | % | Karl Fischer |
| Sulphated ash | max. 0.2 | % | — |
| Assay | 90.0 - 102.0 | % | — |
| Tapped Density | max. 0.6 | g/ml | — |
Table 2 of 3
6 rows| Characteristic | Value | Unit |
|---|---|---|
| Total Plate Count | max. 10³ | cfu/g |
| Total Yeast and Molds Count | max. 10² | cfu/g |
| Enterobacteriae | max. 10² | PNB/g |
| Salmonella | Absence | /10g |
| Escherichia coli | Absence | /g |
| Staphylococcus aureus | Absence | /g |
Table 3 of 3
1 row| Characteristic | Value | Unit |
|---|---|---|
| Isorhoifolin (C) | max. 3 | % |
