Cranberex® Cranberry Extract

3 years in sealed container(s) under a controlled room or cool temperature; low humidity environment; away from light.

The recent, multicentric randomized, double blind clinical trial clearly affirmed, for the first time, a bacterial anti-adhesion effect in urine, based upon 36 mg/day of cranberry PAC (by BL-DMAC method). It also reported that effectiveness was dose-dependent, prolonged up to 24 hours with 72 mg of PAC, and increasing with the amount of PAC (by BL-DMAC method) consumed. Cranberex® is standardized to 15% PACs, and provides these dosages with consumption of 480mg (72mg PAC) and 240mg (36mg PAC) respectively.

North Americans have used cranberries for centuries as a valuable and nutritious food source, but in recent years cranberry's therapeutic use has focused primarily on the ability to support urinary tract health, particularly for those prone to recurrent UTI's.; The constituent in cranberry responsible for its therapeutic effect was for long a matter of speculation. Today scientific consensus is that cranberry's activity is due to its unique proanthocyanidins (PAC's) containing the 'A-type' linkages, not found in PAC's from other sources. Cranberex® is standardized to a high level (15%) of these 'A-type' linkage PAC's.; Anti-Adhesion Activity (AAA) of cranberry : Cranberries support UTH in a unique way: the A-Type PACs inhibit the adhesion of E.coli bacteria to walls of the urinary tract. Studies have confi rmed that this eff ect is specifi c to the A-linked PAC's (cranberry), but not to other PAC rich foods with the more common B-type linkages (e.g. chocolate and grapes) [1]. As this bacterial anti-adhesion mechanism does not kill bacteria, there is less chance of selection for resistant bacterial strains. This has been considered as an advantage compared to antibiotics treatment for UTI's and in some cases more eff ective in reducing the re-occurrence of UTI's.

Control points verified at ENI Internal Quality Control Lab and/or an FDA Registered lab in accordance with ENI product approval and testing protocol (ENI.SOP.H.1).. Extracted by Distilled Water with extract ratio of approximate 200-250:1 (fresh fruit basis); non-GMO Ethanol is used at elution step; no excipient or carrier is used; Non-GMO; ETO-free and not irradiated; residual solvents comply with USP <467>.