Shin-Etsu AQOAT® AS-HF

Other characteristics

Brand

Shin-Etsu AQOAT

Functions

Carrier, Coating System, Controlled Release Agent, Extended Release Agent, Solubilizer

Dosage Form

• Capsules, Pellets, Tablets
• Capsules
• Pellets
• Tablets

Labeling Claims

Allergen-free, BSE-free, Kosher, Non-GMO, Solvent-free, TSE-free; Allergen-free; BSE-free; Kosher; Non-GMO; Solvent-free; TSE-free

Certifications & Compliance

DMF Type IV, GMP, Japan Pharmacopeia (JP), National Formulary (NF), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA)

Note

*Viscosity of 2 w/w% solution of sodium hydroxide aqueous solution at 20oC **D 50: NMT10 μm, D 90: NMT20 μm by laser diffraction method ***D 50: 70 - 300 μm by laser diffraction method Abbreviation; HPMCAS

Grade

Pharma Grade

Markets

Healthcare & Pharma

Features

For enteric coating, various coating methods can be applied such as aqueous, organic solvent, ammonia neutralized and dry coating. Coating methods can be selected depending on the characteristic of API. For example, dry coating is suitable for water and solvent sensitive API.. Shin-Etsu AQOAT® is also used in solid dispersion for solubility and bioavailability enhancement. In order to prepare solid dispersion, various methods are applicable such as spray dry, spray coating, hot melt extrusion (HME), coprecipitation etc. As Shin-Etsu AQOAT® can dissolve into various organic solvents and has relatively low glass transition temperature (Tg), it is one of the most suitable polymers in solid dispersion. Numerous scientific papers reported that Shin-Etsu AQOAT® was able to enhance the drug solubility more effectively compared to other polymers.

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Technology

Pharmaceuticals & Nutraceuticals

Packaging Type

• Bags
• Drums

Chemical Inventories

• ENCS (Japan)
• IECSC (China)
• KECI (Korea)
• TCSI (Taiwan)

Certifications and Compliance

DMF Type IV; GMP; Japan Pharmacopeia (JP); National Formulary (NF); The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA)