Dermapep™ A4000

DermaPep™ A4000 is a mixture of DermaPep™ A420 and DermaPep™ A510. The former is a mimic peptide of TGF-β and the latter a pentapeptide fragment derived from collagen type I. DermaPep™ A420 plays a prominent role in the accumulation of ECM components by increasing expression of ECM genes such as collagen and fibronectin. DermaPep™ A510 stimulates the synthesis of collagen type I and Ⅳ. In vivo and in vitro study results show that DermaPep™ A4000 works synergistically to fight against aging. There was an excellent improvement in terms of reduction of fine lines and wrinkles by DermaPep™ A420 and a decrease of wrinkle depth and volume by DermaPep™ A510 in vivo. Surprisingly, the combination of both peptides showed more profound effect on collagen synthesis than either peptide alone in vitro. DermaPep™ A4000 is therefore effective and powerful tools to maintain skin dermal thickness and to fight against signs of aging.