Instacoat Aqua
Instacoat™ Aqua is a general-purpose film coating system consisting of a dry blend of polymers, plasticizers, pigments, opacifier and other excipients. The system is optimized to give superior tablet finish using water as the solvent system.
Properties
- Pharma and Nutraceuticals Functions
- Coating System
Product families
Applications
- Excipients & Coatings
Product Families
- Pharmaceutical Coatings
Other characteristics
- Brand
- Instacoat
- Functions
- Coating System
- Markets
- Healthcare & Pharma
- Benefits
Facilitates product registration in multiple regulatory environments.; Coatings are smooth, glossy and resilient to physical damage. Packaging speeds are enhanced.; Solids levels up to 11% facilitate rapid coating.; Rapid suspension preparation.; Minimal impact on dissolution and disintegration.; Avoids use of expensive super-disintegrants.; Aqueous processing promotes a safe working environment and avoidance of atmospheric pollution.; Easy scale-up and transfer to different equipment types or manufacturing sites.; Meeting diverse marketing requirements is facilitated.
- Features
Single polymer, HPMC with wide history of pharma/nutritional use.; Formulated for lower viscosity than other HPMC systems.; HPMC is highly water soluble.; Can be applied in a wide range of equipment designs and sizes from most manufacturers.; White or ready colored systems are available. Anti-counterfeiting and branding features can be built-in.
- Technology
- Pharmaceuticals & Nutraceuticals
- Typical Constituents
HPMC; Plasticiser; Titanium Dioxide; Edible Pigments, Glidant.
- Reconstitution Process
Add the weighed quantity of water to a mixing vessel.; Using a mechanical stirrer, stir the purified water to form a vortex.; Add required quantity of Instacoat Aqua II to the center of the liquid vortex in a slow steady stream, avoiding clumping while maintaining a vortex. Once the entire quantity of Instacoat has been added, reduce the stirrer speed to eliminate the vortex. Continue mixing for 45 minutes.
- Regulatory Information
All products are checked for the regulatory compliance of all ingredients in the target countries and market segments of sale. This determination is made at the time the initial formulation is established, based on customer-supplied information. If market countries and/or segments are extended once the formulation has been established, customers are encouraged to contact us to ensure that regulatory compliance is not compromised.
- Equipment / Accessories
- Variable-speed mechanical stirrer
- Mixing Vessel
- Manufacturing Technology
- Tablet Coating
- Recommended Process Conditions
Tablet bed temperature offers the most effective way of controlling the coating process. Where this measurement is unavailable, exhaust temperature may be substituted. However, the relationship between the two measurements is complex and depends on several factors such as pan load, pan depression, pan design and airflow rate. Indicated exhaust temperature may be above or below the true bed temperature. It is recommended that the relationship between the two measurements is calibrated.
- Recommended Solvent System and Reconstitution Level
- Purified water at up to 11% w/w solids.
- Calculation of Instacoat™ Aqua and Solvent Quantities
Determine the quantities of Instacoat Aqua (11% w/w solids) and water required based on the quantity of tablets to be coated and the target coating weight gain. e.g.: For coating 1.0 kg of tablets to 3% wt. gain, weigh 33 g Instacoat and 267 gm purified water at room temperature (includes 10% overage for losses).
