Instacoat EHP 250
Instacoat™ EHP 250 is a fully formulated high performance aqueous film coating system. It is a single polymer PVA based coating system having excellent water solubility, able to perform at high reconstitution levels up to 25% with excellent process performance in all types of conventional and side-vented coating equipment.
Properties
- Pharma and Nutraceuticals Functions
- Coating System
- Detackifier
Product families
Applications
- Oral
- Excipients & Coatings
Product Families
- Formulation & Processing Aids
- Pharmaceutical Coatings
Other characteristics
- Brand
- Instacoat
- Functions
- Coating System, Detackifier
- Markets
- Healthcare & Pharma
- Benefits
Coatings are smooth, glossy and resilient to physical damage. Packaging speeds are enhanced.; Solids levels up to 25% facilitate rapid coating thus significant productivity gains.; Minimal impact on dissolution and disintegration.; Avoids use of expensive super-disintegrants in tablet core.; Aqueous processing promotes a safe working environment and avoidance of atmospheric pollution.; Excellent logo definition and freedom from coating faults such as logo bridging.; Overcomes PVA tack issues and contributes to productivity gains.; Avoidance of regulatory issues.; Easy scale-up and transfer to different equipment types or manufacturing sites.
- Features
PVA is a low viscosity polymer.; PVA is highly water soluble.; PVA is a highly adhesive polymer which is supported by an adhesion enhancing excipient.; Anti-tack agent.; Soya lecithin is excluded.; Can be applied in a wide range of equipment designs and sizes from most manufacturers.
- Technology
- Pharmaceuticals & Nutraceuticals
- Typical Constituents
PVA; Plasticiser; Titanium Dioxide; Edible Pigments, Anti-Tack & Adhesion Enhancing agents.
- Reconstitution Process
Add the weighed quantity of water to a mixing vessel.; Using a mechanical stirrer, stir the purified water to form a vortex.; Add required quantity of Instacoat EHP 250 to the center of the liquid vortex in a slow steady stream, avoiding clumping while maintaining a vortex. Once the entire quantity of Instacoat has been added, reduce the stirrer speed to eliminate the vortex. Continue mixing for 45 minutes.
- Regulatory Information
All products are checked for the regulatory compliance of all ingredients in the target countries and market segments of sale. This determination is made at the time the initial formulation is established, based on customer-supplied information. If market countries and/or segments are extended once the formulation has been established, customers are encouraged to contact us to ensure that regulatory compliance is not compromised.
- Equipment / Accessories
- Variable-speed mechanical stirrer
- Mixing Vessel
- Manufacturing Technology
- Tablet Coating
- Recommended Process Conditions
Tablet bed temperature offers the most effective way of controlling the coating process. Where this measurement is unavailable, exhaust temperature may be substituted. However, the relationship between the two measurements is complex and depends on several factors such as pan load, pan depression, pan design and airflow rate. Indicated exhaust temperature may be above or below the true bed temperature. It is recommended that the relationship between the two measurements is calibrated.
- Recommended Solvent System and Reconstitution Level
- Purified water at up to 25% w/w solids.
- Calculation of Instacoat™ EHP 250 and Solvent Quantities
Determine the quantities of Instacoat EHP (25% w/w solids) and water required based on the quantity of tablets to be coated and the target coating weight gain. e.g.: For coating 1.0 kg of tablets to 3% wt. gain, weigh 33 g Instacoat and 99 gm purified water at room temperature (includes 10% overage for losses)
