Instacoat EMB
Instacoat™ EMB is a fully formulated high performance aqueous film coating system optimized as a moisture barrier. High solids capability combined with low viscosity and high substrate adhesion provide a system with excellent process performance that can be used in all types of coating equipment.
Properties
- Pharma and Nutraceuticals Functions
- Coating System
- Moisture Barrier Coating
Product families
Applications
- Oral
- Pharmaceutical Processing
Product Families
- Pharmaceutical Coatings
Other characteristics
- Brand
- Instacoat
- Functions
- Coating System, Moisture Barrier Coating
- Markets
- Healthcare & Pharma
- Benefits
Reduces degradation of moisture sensitive APIs enabling extension of shelf-life and cost reductions via use of lower cost packaging.; Coatings are smooth, glossy and resilient to physical damage. Packaging speeds are enhanced.; Solids levels up to 20 % facilitate rapid coating thus major productivity gains.; Rapid suspension preparation.; Minimal impact on dissolution and disintegration.; Avoids use of expensive super-disintegrants in tablet core.; Aqueous processing promotes a safe working environment and avoidance of atmospheric pollution.; Easy scale-up and transfer to different equipment types or manufacturing sites.; Suitable for batch and continuous processes.; Facilitates product registration in multiple regulatory environments
- Features
PVA is an excellent moisture barrier.; Subsidiary elements chosen to reduce hydrophilicity.; PVA is a low viscosity polymer.; PVA is highly water soluble.; Can be applied in a wide range of equipment designs and sizes from most manufacturers.; Single polymer and absence of soya lecithin and talc.
- Technology
- Pharmaceuticals & Nutraceuticals
- Typical Constituents
PVA; Plasticiser; Titanium Dioxide; Edible Pigments, Anti-tack Agent.
- Reconstitution Process
Add the weighed quantity of water to a mixing vessel.; Using a mechanical stirrer, stir the purified water to form a vortex.; Add required quantity of Instacoat EMB to the center of the liquid vortex in a slow steady stream, avoiding clumping while maintaining a vortex. Once the entire quantity of Instacoat has been added, reduce the stirrer speed to eliminate the vortex. Continue mixing for 45 minutes.
- Regulatory Information
All products are checked for the regulatory compliance of all ingredients in the target countries and market segments of sale. This determination is made at the time the initial formulation is established, based on customer-supplied information. If market countries and/or segments are extended once the formulation has been established, customers are encouraged to contact us to ensure that regulatory compliance is not compromised.
- Equipment / Accessories
- Variable-speed mechanical stirrer
- Mixing Vessel
- Recommended Process Conditions
Tablet bed temperature offers the most effective way of controlling the coating process. Where this measurement is unavailable, exhaust temperature may be substituted. However, the relationship between the two measurements is complex and depends on several factors such as pan load, pan depression, pan design and airflow rate. Indicated exhaust temperature may be above or below the true bed temperature. It is recommended that the relationship between the two measurements is calibrated.
- Recommended Solvent System and Reconstitution Level
- Purified water at up to 20% w/w solids.
- Calculation of Instacoat™ EMB and Solvent Quantities
Determine the quantities of Instacoat EMB (20% w/w solids) and water required based on the quantity of tablets to be coated and the target coating weight gain. e.g.: For coating 1.0 kg of tablets to 3% wt. gain, weigh 33 g Instacoat and 132 gm purified water at room temperature (includes 10% overage for losses).
