PolyStardone® XL-10

Other characteristics

Brand

PolyStardone

Synonyms

1-Vinyl-2-pyrrolidinone polymer, 1-Vinyl-2-pyrrolidone homopolymer, 1-Vinyl-2-pyrrolidone polymer, 1-Vinylpyrrolidin-2-one homopolymer, n-Octyl mercaptan-N-vinylpyrrolidone copolymer, N-Vinyl-2-pyrolidone homopolymer, N-Vinyl-2-pyrrolidinone homopolymer, N-Vinyl-2-pyrrolidone homopolymer, N-Vinyl-2-pyrrolidone polymer, N-Vinylbutyrolactam polymer, N-Vinylpyrrolidinone homopolymer, N-Vinylpyrrolidinone polymer, N-Vinylpyrrolidone homopolymer, N-Vinylpyrrolidone polymer, Poly(1-vinyl-2-pyrrolidinone), Poly(1-vinyl-2-pyrrolidone), Poly(1-vinylpyrrolidinone), Poly(N-vinyl-2-pyrrolidinone), Poly(N-vinyl-2-pyrrolidone), Poly(N-vinyl-γ-butyrolactam), Poly(N-vinylbutyrolactam), Poly(N-vinylpyrrolidinone), Poly(N-vinylpyrrolidone), Poly(vinylpyrrolidinone), Poly(vinylpyrrolidone), Polyvinyl polypyrrolidone, Polyvinylpyrrolidone, Povidone, Vinylpyrrolidinone polymer, Vinylpyrrolidone homopolymer, Vinylpyrrolidone polymer

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Functions

Disintegrant

Certifications & Compliance

Chinese Pharmacopeia (ChP), European Pharmacopeia (Ph. Eur.), Japan Pharmacopeia (JP), National Formulary (NF), United States Pharmacopeia (USP)

Grade

Pharma Grade

Markets

Healthcare & Pharma

Summary

The case study demonstrates the effectiveness of PolyStardone® as a super disintegrant for a tablet matrix containing both water-soluble (lactose) and insoluble (dibasic calcium phosphate), mediumcompactable fillers. The performance of PolyStardone® was compared to other crospovidone products in the market. We believe that: PolyStardone® XL and PolyStardone® XL-10 have similar performance to import competitor A and import B, and are better than domestic competitor C and D in terms of compactibility and disintegration capabilities. In this case, PolyStardone® XL ensures rapid disintegration regardless of compaction force. Furthermore, PolyStardone® XL-10 offers additional benefits in increasing tablet tensile strength without a compromise in its disintegration efficiency.

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Features

Physical Properties : Non-ionic polymer High porosity and hydration Easy compression and viscoelastic deformation No gel formation Stable in acids and bases; Performance Impact :; No interaction with ionic APIs (i.e. Ranitidine, Cetirizine) Combines wicking and swelling mechanisms to achieve rapid tablet disintegration at low concentrations(1-5%) Increased tablet tensile strength and reduced friability due to high compressibility. Especially suitable for poorly compressible APIs No gel formation even at higher concentrations (10%), idea for ODTs Suitable for a variety of pH sensitive formulations

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Appearance

White or yellowish-white powder

Application

Insoluble in water or common organic solvents, the powder particles are porous microstructures with high specific surface area.. As a super disintegretant, it will not form gel and can effectively improve the disintegration time.

Dosage Form

Powder & Powder Blends

Technology

Pharmaceuticals & Nutraceuticals

Packaging Type

• Bags
• Drums

Packaging and Storage

Packed in 20 kg fiber drum or 15 kg plastic drum, inner lined with PE bags; Special packing is available according to customer's requirement; Preserve in tight containers

Certifications and Compliance

• Chinese Pharmacopeia (ChP)
• European Pharmacopeia (Ph. Eur.)
• Japan Pharmacopeia (JP)
• National Formulary (NF)
• United States Pharmacopeia (USP)