Stardone® VA64
- CAS Number
- 25086-89-9
- EC Number
- 607-540-1
- Chemical Name
- Copovidone
Stardone® VA64 is an excellent direct compression binder. the ultimate tablet binder for all processing technologies. The vinyl acetate component in Stardone®VA64 reduces the hydrophilicity and glass transition temperature (Tg) compared to Povidone K30 of similar molecular weight. Several technologies are available: the preferred direct compression, wet granulation, and dry granulation, as well as hot melt extrusion for poorly soluble drug actives with low bioavailability.
Properties
- Physical Form
- Powder
- Solid
- Pharma and Nutraceuticals Functions
- Binder
- Film Former
Product families
Applications
- Oral
Product Families
- Binders & Disintegrants
- Pharmaceutical Coatings
Other characteristics
- Brand
- Stardone
- Synonyms
- PVP/VA, PVP/VA Copolymer
- Functions
- Binder, Film Former
- Certifications & Compliance
Chinese Pharmacopeia (ChP), European Pharmacopeia (Ph. Eur.), Japan Pharmacopeia (JP), National Formulary (NF), United States Pharmacopeia (USP)
- Grade
- Pharma Grade
- Markets
- Healthcare & Pharma
- Summary
A direct compression formulation of acetylsalicylic acid was achieved with Stardone®VA64. Although acetylsalicylic acid is known to be poorly compressible, the formulation resulted in robust tablets with low friability at all compaction forces, as well as good disintegration times. Stardone®VA64 has similar performance to import competitor A and import B in terms of tablet hardness, friability, and disintegration time.
- Features
Physical Properties: Non-ionic polymer Low hygroscopic Good plastic deformation Good fluidity and compressibility Low glass transition temperature; Performance Impact:; No interaction with ionic APIs The vinyl acetate component in Stardone®VA64 reduces the hydrophilicity The vinyl acetate component has greatly improved the plasticity of Stardone®VA64, making it exceptionally well as a binder for direct compression Hollow particle morphology provides good fluidity of Stardone®VA64, and large surface area enhances the bonding and compressibility of particles Ideal glass transition temperature(Tg) for hot melt extrusion; Direct Compression : Excellent binder at 2-10% with other direct compression binder-fillers such as MCC, dicalcium phosphate, etc.; Dry Granulation :Can be used as a binder in dry granulation(roller compaction).; Wet Granulation:Enables wet granulation of moisture sensitive due to low hygroscopicity.; Hot Melt Extrusion: Acts as a polymer matrix for solid dispersions/solutions via hot melt extrusion due idea glass transition temperature at 105℃; Film Coating: Ideally suited as co-film-former
- Technology
- Pharmaceuticals & Nutraceuticals
- Packaging Type
- Bags
- Drums
- Manufacturing Technology
- Direct Compression
- Dry Granulation
- Wet Granulation
- Certifications and Compliance
- Chinese Pharmacopeia (ChP)
- European Pharmacopeia (Ph. Eur.)
- Japan Pharmacopeia (JP)
- National Formulary (NF)
- United States Pharmacopeia (USP)
