PTSC
- CAS Number
- 98-59-9
- EC Number
- 202-684-8
- Chemical Name
- p-Toluenesulfonyl Chloride
- Chemical Family
- Sulfonyl Chlorides
PTSC stands for para toluene sulfonylchloride also named tosylchloride or abbreviated TsCl. It serves as intermediate in pharmaceutics and in various chemical synthesis.
Properties
- Physical Form
- Powder
- Solid
- Pharma and Nutraceuticals Functions
- API Intermediate
Product families
Applications
- Chemical Manufacturing
- Resin Manufacturing
- API Manufacturing
Product Families
- Alkylating & Acylating Agents
- Intermediates & Precursors
Other characteristics
- Brand
- PTSC
- Functions
- API Intermediate, Reagent
- Notes
*Little colored spots can be found on the surface of the powder due to moisture condensation.
- Markets
- Healthcare & Pharma
- Industrial
- Storage
- Store in a cool dry place.
- PACKAGING
• 25 kg polyethylene drums, 24 on a pallet. • 100 kg polyethylene drums, 4 on a pallet.
- Appearance
- White Crystalline Powder*
- Application
PTSC is an intermediate in chemical and pharmaceutical synthesis. Among others it is an activation agent in the synthesis of organic compounds. One major application of PTSC is the tosylation of alcohols in order to activate the group for conversion at a later step in the synthesis. Through the use of PTSC an alcohol can be converted into an excellent leaving group, as depicted in below schema: R-OH + TsCl → R-OTs + HCl R-OTs + NH3 → R-NH2 + HOTs NH3 is taken as example but it can be done with any organic nucleophile. PTSC is also used to convert carboxylic acids into phenolic esters through the use of the weak nucleophiles like phenols. Many pharmaceuticals are prepared with PTSC as activating agent as for example: • Flupentixol (psychiatric drug) • Thiometon (pesticide) • Deltamethrine (pesticide) • Diboc (protecting agent) • Cefotaxime (antibiotic) • MDMA (psychiatric drug)
- Technology
- Base Chemicals & Intermediates
- Pharmaceuticals & Nutraceuticals
- Packaging Type
- Drums
- Applicable Processes
- Electroplating
- Base Chemicals End Uses
- Amide
- Dye
- Herbicide
- Pharmaceutical Application
- Resins
- Base Chemicals Functions
- Reagent
- Certifications and Compliance
- REACH (Europe)
Technical data
Table 1 of 2
3 rows| Characteristic | Value | Unit |
|---|---|---|
| Apparent Bulk Density | 660 - 730 | kg/m3 |
| Boiling Point (1.33 Kpa) | 135.5 | °C |
| Flash Point (Closed Cup) | 128 | °C |
Table 2 of 2
6 rows| Characteristic | Value | Unit |
|---|---|---|
| Active Content | min. 99.5 | % |
| Water Content | max. 0.1 | % |
| Crystallisation Point | min. 66.9 | °C |
| Colour (25 % Solution in Acetone) | max. 40 | Pt/Co |
| P-Toluenesulfonic Acid | max. 0.2% | % |
| O-Toluenesulfonylchloride | max. 0.3% | % |
