ZEOsphere® DRP A5

Purification of charged API currently processed via reversed phase and/or ion-exchange chromatography. The unique method of ZEOsphere® DRP (Doped Reversed Phase) is based on attraction-repulsion by merging a high performance reversed-phase with ion-exchange (anion or cation) material.. ZEOsphere® DRP. Mixed mode. Spherical silica gel. Highly efficient and extremely powerful.

Peptides; Although reversed phase has proven to be an acceptable technique, its selectivity shortcomings and enormous costs have urged the need for more efficient separation techniques.; ZEOsphere® DRPs orthogonality leads to enhanced separation.; Sharper peaks, faster retention, better selectivity. Significant yield improvement. Lower organic solvent consumption.; Insulins; In crude insulins, differences in structures are very minimal. Presently used separation techniques like ionexchange and reversed phase lead to low production efficiency due to inadequate selectivity.; Dual interaction ZEOsphere® DRP. Substantially increased selectivity. Higher yield and loadability. Enhanced productivity.; Oligonucleotides; Synthetic oligonucleotides gain increasing importance in new therapeutic concepts.; Standard used reversed phase chromatography shows insufficient and strongly retained separation, which leads to low yields and a subsequent increase in costs.; ZEOsphere® DRP produces improved selectivity. Substantial higher yields. Unequaled efficiency.

Cyano (Can be used in both NP & RP systems); Diol (Can be used in both NP & RP systems); NH2 (Can be used in both NP & RP systems); Thiol (SH) & NH2 phases available for scavenging electrophiles and toxic heavy metals